Assay Detail
Functional
CHEMBL704903
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Concentration inhibiting L1210 cell growth in culture
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.85 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431359 | — | — | 1 | 9.62 |
| CHEMBL296373 | EDATREXATE | 2.0 | 1 | 9.19 |
| CHEMBL293263 | — | — | 1 | 8.82 |
| CHEMBL302068 | — | — | 1 | 8.33 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431359 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL296373 | EDATREXATE | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL293263 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL302068 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 5.0 | nM | 8.30 |