Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL704904

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro growth inhibition of murine leukemia L1210 cells after 40 hours exposure.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Potential antitumor agents. 53. Synthesis, DNA binding properties, and biological activity of perimidines designed as "minimal" DNA-intercalating agents.
Herbert JM, Woodgate PD, Denny WA.
J Med Chem (1987) 30 : 2081 -2086
PubMed 3669016 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.47 6.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL66428 1 6.36
CHEMBL431958 1 6.06
CHEMBL63142 1 5.96
CHEMBL65680 1 5.89
CHEMBL417031 1 5.82
CHEMBL20330 1 5.80
CHEMBL65045 1 5.75
CHEMBL65678 1 5.72
CHEMBL444530 1 5.66
CHEMBL304941 1 5.60
CHEMBL61569 1 5.40
CHEMBL417404 1 5.24
CHEMBL62662 1 4.85
CHEMBL65251 1 4.82
CHEMBL63722 1 4.78
CHEMBL65302 1 4.70
CHEMBL63433 1 4.66
CHEMBL63617 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL66428 IC50 = 440.0 nM 6.36
CHEMBL431958 IC50 = 870.0 nM 6.06
CHEMBL63142 IC50 = 1100.0 nM 5.96
CHEMBL65680 IC50 = 1300.0 nM 5.89
CHEMBL417031 IC50 = 1500.0 nM 5.82
CHEMBL20330 IC50 = 1600.0 nM 5.80
CHEMBL65045 IC50 = 1800.0 nM 5.75
CHEMBL65678 IC50 = 1900.0 nM 5.72
CHEMBL444530 IC50 = 2200.0 nM 5.66
CHEMBL304941 IC50 = 2500.0 nM 5.60
CHEMBL61569 IC50 = 4000.0 nM 5.40
CHEMBL417404 IC50 = 5700.0 nM 5.24
CHEMBL62662 IC50 = 14100.0 nM 4.85
CHEMBL65251 IC50 = 15300.0 nM 4.82
CHEMBL63722 IC50 = 16700.0 nM 4.78
CHEMBL65302 IC50 = 20000.0 nM 4.70
CHEMBL63433 IC50 = 21700.0 nM 4.66
CHEMBL63617 IC50 > 21000.0 nM -