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Assay Detail

CHEMBL705012

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Functional
Cytotoxic property against K562 cell line was determined
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type K562
Confidence 1 — Organism
Curated By Expert

Target

K562 (CHEMBL385)
Type CELL-LINE
Organism Homo sapiens

Publication

2,6,8,9-tetrasubstituted purines as new CDK1 inhibitors.
Moravec J, Krystof V, Hanus J, Havlícek L, Moravcová D, Fuksová K, Kuzma M, Lenobel R, Otyepka M, Strnad M.
Bioorg Med Chem Lett (2003) 13 : 2993 -2996
PubMed 12941319 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.64 5.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL102871 1 5.85
CHEMBL103567 1 5.46
CHEMBL23327 PURVALANOLA 1 5.05
CHEMBL317865 1 4.70
CHEMBL103272 1 4.68
CHEMBL101166 1 4.57
CHEMBL320873 1 4.57
CHEMBL318289 1 4.52
CHEMBL14762 SELICICLIB 2.0 1 4.40
CHEMBL100645 1 4.24
CHEMBL100670 1 4.13
CHEMBL100500 1 4.10
CHEMBL100079 1 4.04
CHEMBL99782 1 -
CHEMBL447237 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL102871 IC50 = 1400.0 nM 5.85
CHEMBL103567 IC50 = 3500.0 nM 5.46
CHEMBL23327 PURVALANOLA IC50 = 9000.0 nM 5.05
CHEMBL317865 IC50 = 20000.0 nM 4.70
CHEMBL103272 IC50 = 21000.0 nM 4.68
CHEMBL101166 IC50 = 27000.0 nM 4.57
CHEMBL320873 IC50 = 27000.0 nM 4.57
CHEMBL318289 IC50 = 30000.0 nM 4.52
CHEMBL14762 SELICICLIB IC50 = 40000.0 nM 4.40
CHEMBL100645 IC50 = 58000.0 nM 4.24
CHEMBL100670 IC50 = 74000.0 nM 4.13
CHEMBL100500 IC50 = 80000.0 nM 4.10
CHEMBL100079 IC50 = 91000.0 nM 4.04
CHEMBL99782 IC50 = 154000.0 nM -
CHEMBL447237 IC50 = 117000.0 nM -