Assay Detail
Functional
CHEMBL705013
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Cytotoxic effect in K562 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis of pyrimidinopyridine-triazene conjugates targeted to abl tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.18 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL941 | IMATINIB | 4.0 | 1 | 6.96 |
| CHEMBL109329 | — | — | 1 | 5.67 |
| CHEMBL230286 | — | — | 1 | 5.50 |
| CHEMBL326925 | — | — | 1 | 5.27 |
| CHEMBL112245 | — | — | 1 | 5.00 |
| CHEMBL113302 | — | — | 1 | 5.00 |
| CHEMBL113486 | — | — | 1 | 4.79 |
| CHEMBL113534 | — | — | 1 | 4.76 |
| CHEMBL57553 | — | — | 1 | 4.66 |
| CHEMBL326753 | — | — | 1 | 4.17 |
| CHEMBL810 | TEMOZOLOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL941 | IMATINIB | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL109329 | — | IC50 | = | 2164.0 | nM | 5.67 |
| CHEMBL230286 | — | IC50 | = | 3151.0 | nM | 5.50 |
| CHEMBL326925 | — | IC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL112245 | — | IC50 | = | 10110.0 | nM | 5.00 |
| CHEMBL113302 | — | IC50 | = | 9880.0 | nM | 5.00 |
| CHEMBL113486 | — | IC50 | = | 16180.0 | nM | 4.79 |
| CHEMBL113534 | — | IC50 | = | 17350.0 | nM | 4.76 |
| CHEMBL57553 | — | IC50 | = | 21690.0 | nM | 4.66 |
| CHEMBL326753 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL810 | TEMOZOLOMIDE | IC50 | = | 156100.0 | nM | - |