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Assay Detail

CHEMBL705091

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against rhinoviral 14 serotype in a plaque inhibition assay using monolayers of M-HeLa cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human rhinovirus sp.
Cell Type HeLa
Confidence 1 — Organism
Curated By Expert

Target

Human rhinovirus sp. (CHEMBL612470)
Type ORGANISM
Organism Human rhinovirus sp.

Publication

Synthesis and antirhinovirus activity of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)-9H-purines.
Kelley JL, Linn JA, Selway JW.
J Med Chem (1989) 32 : 1757 -1763
PubMed 2547069 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.16 5.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL283830 1 5.92
CHEMBL301387 1 5.37
CHEMBL50299 1 5.18
CHEMBL51721 1 5.16
CHEMBL51383 1 5.15
CHEMBL49821 1 5.15
CHEMBL300881 1 5.15
CHEMBL48312 1 5.12
CHEMBL298184 1 5.12
CHEMBL48774 1 5.10
CHEMBL48702 1 5.10
CHEMBL299959 1 5.10
CHEMBL48926 1 5.09
CHEMBL51194 1 5.07
CHEMBL49668 1 5.05
CHEMBL49403 1 5.02
CHEMBL299013 1 5.00
CHEMBL301081 1 4.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL283830 IC50 = 1200.0 nM 5.92
CHEMBL301387 IC50 = 4300.0 nM 5.37
CHEMBL50299 IC50 = 6600.0 nM 5.18
CHEMBL51721 IC50 = 7000.0 nM 5.16
CHEMBL51383 IC50 = 7100.0 nM 5.15
CHEMBL49821 IC50 = 7100.0 nM 5.15
CHEMBL300881 IC50 = 7100.0 nM 5.15
CHEMBL48312 IC50 = 7600.0 nM 5.12
CHEMBL298184 IC50 = 7500.0 nM 5.12
CHEMBL48774 IC50 = 8000.0 nM 5.10
CHEMBL48702 IC50 = 8000.0 nM 5.10
CHEMBL299959 IC50 = 8000.0 nM 5.10
CHEMBL48926 IC50 = 8100.0 nM 5.09
CHEMBL51194 IC50 = 8600.0 nM 5.07
CHEMBL49668 IC50 = 9000.0 nM 5.05
CHEMBL49403 IC50 = 9600.0 nM 5.02
CHEMBL299013 IC50 = 10000.0 nM 5.00
CHEMBL301081 IC50 = 11000.0 nM 4.96