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Assay Detail

CHEMBL705262

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro cytotoxicity against L1210 (murine leukemia) cells.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Molecular requirements for targeting the polyamine transport system. Synthesis and biological evaluation of polyamine-anthracene conjugates.
Wang C, Delcros JG, Biggerstaff J, Phanstiel O.
J Med Chem (2003) 46 : 2672 -2682
PubMed 12801231 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.33 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL421884 1 6.52
CHEMBL92270 1 6.40
CHEMBL88881 1 6.40
CHEMBL328320 1 6.16
CHEMBL91845 1 5.89
CHEMBL89918 1 5.75
CHEMBL89779 1 5.64
CHEMBL327423 1 5.37
CHEMBL314451 1 5.19
CHEMBL89204 1 5.15
CHEMBL88609 1 5.14
CHEMBL419870 1 5.12
CHEMBL91896 1 4.99
CHEMBL91733 1 4.97
CHEMBL83536 1 4.85
CHEMBL92204 1 4.84
CHEMBL91476 1 4.75
CHEMBL88898 1 4.71
CHEMBL88868 1 4.66
CHEMBL82888 1 4.00
CHEMBL81361 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL421884 IC50 = 300.0 nM 6.52
CHEMBL92270 IC50 = 400.0 nM 6.40
CHEMBL88881 IC50 = 400.0 nM 6.40
CHEMBL328320 IC50 = 700.0 nM 6.16
CHEMBL91845 IC50 = 1300.0 nM 5.89
CHEMBL89918 IC50 = 1800.0 nM 5.75
CHEMBL89779 IC50 = 2300.0 nM 5.64
CHEMBL327423 IC50 = 4300.0 nM 5.37
CHEMBL314451 IC50 = 6400.0 nM 5.19
CHEMBL89204 IC50 = 7100.0 nM 5.15
CHEMBL88609 IC50 = 7200.0 nM 5.14
CHEMBL419870 IC50 = 7500.0 nM 5.12
CHEMBL91896 IC50 = 10200.0 nM 4.99
CHEMBL91733 IC50 = 10700.0 nM 4.97
CHEMBL83536 IC50 = 14000.0 nM 4.85
CHEMBL92204 IC50 = 14600.0 nM 4.84
CHEMBL91476 IC50 = 18000.0 nM 4.75
CHEMBL88898 IC50 = 19500.0 nM 4.71
CHEMBL88868 IC50 = 21800.0 nM 4.66
CHEMBL82888 IC50 = 99000.0 nM 4.00
CHEMBL81361 IC50 > 100000.0 nM -