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Assay Detail

CHEMBL705263

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro cytotoxicity was determined against alpha-difluoromethylornithine treated L1210 (murine leukemia) cells.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Molecular requirements for targeting the polyamine transport system. Synthesis and biological evaluation of polyamine-anthracene conjugates.
Wang C, Delcros JG, Biggerstaff J, Phanstiel O.
J Med Chem (2003) 46 : 2672 -2682
PubMed 12801231 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.73 6.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL421884 1 6.82
CHEMBL92270 1 6.70
CHEMBL88881 1 6.52
CHEMBL328320 1 6.52
CHEMBL89779 1 6.22
CHEMBL327423 1 6.22
CHEMBL91845 1 6.16
CHEMBL89918 1 5.85
CHEMBL419870 1 5.80
CHEMBL314451 1 5.68
CHEMBL91476 1 5.66
CHEMBL88609 1 5.42
CHEMBL89204 1 5.37
CHEMBL91896 1 5.29
CHEMBL91733 1 5.14
CHEMBL92204 1 4.66
CHEMBL88868 1 4.66
CHEMBL88898 1 4.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL421884 IC50 = 150.0 nM 6.82
CHEMBL92270 IC50 = 200.0 nM 6.70
CHEMBL88881 IC50 = 300.0 nM 6.52
CHEMBL328320 IC50 = 300.0 nM 6.52
CHEMBL89779 IC50 = 600.0 nM 6.22
CHEMBL327423 IC50 = 600.0 nM 6.22
CHEMBL91845 IC50 = 700.0 nM 6.16
CHEMBL89918 IC50 = 1400.0 nM 5.85
CHEMBL419870 IC50 = 1600.0 nM 5.80
CHEMBL314451 IC50 = 2100.0 nM 5.68
CHEMBL91476 IC50 = 2200.0 nM 5.66
CHEMBL88609 IC50 = 3800.0 nM 5.42
CHEMBL89204 IC50 = 4300.0 nM 5.37
CHEMBL91896 IC50 = 5100.0 nM 5.29
CHEMBL91733 IC50 = 7200.0 nM 5.14
CHEMBL92204 IC50 = 21900.0 nM 4.66
CHEMBL88868 IC50 = 21900.0 nM 4.66
CHEMBL88898 IC50 = 31900.0 nM 4.50