Assay Detail
Functional
CHEMBL705269
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Evaluated for cell growth inhibition of L1210 cells in cultures
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.86 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.68 |
| CHEMBL69016 | — | — | 1 | 7.63 |
| CHEMBL267890 | — | — | 1 | 7.24 |
| CHEMBL66389 | — | — | 1 | 6.31 |
| CHEMBL66864 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL69016 | — | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL267890 | — | IC50 | = | 57.2 | nM | 7.24 |
| CHEMBL66389 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL66864 | — | IC50 | = | 36400.0 | nM | 4.44 |