Assay Detail
Functional
CHEMBL705270
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Evaluated for concentration which when added to cultures of L1210 leukemia cells for a period of 70 hr reduces cell numbers of 50% of control cultures
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.95 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143911 | — | — | 1 | 9.22 |
| CHEMBL423554 | — | — | 1 | 8.54 |
| CHEMBL356047 | — | — | 1 | 8.37 |
| CHEMBL37843 | — | — | 1 | 8.26 |
| CHEMBL358308 | — | — | 1 | 7.82 |
| CHEMBL37656 | — | — | 1 | 7.82 |
| CHEMBL35055 | — | — | 1 | 7.11 |
| CHEMBL287038 | — | — | 1 | 6.80 |
| CHEMBL141493 | — | — | 1 | 6.66 |
| CHEMBL142849 | — | — | 1 | 6.52 |
| CHEMBL286237 | — | — | 1 | 6.37 |
| CHEMBL143532 | — | — | 1 | 6.17 |
| CHEMBL34432 | — | — | 1 | 5.99 |
| CHEMBL291266 | — | — | 1 | 5.86 |
| CHEMBL286563 | — | — | 1 | 5.81 |
| CHEMBL43184 | AMINACRINE | 2.0 | 1 | 5.58 |
| CHEMBL169949 | — | — | 1 | 5.28 |
| CHEMBL289042 | — | — | 1 | - |
| CHEMBL35478 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143911 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL423554 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL356047 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL37843 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL358308 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL37656 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL35055 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL287038 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL141493 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL142849 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL286237 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL143532 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL34432 | — | IC50 | = | 1025.0 | nM | 5.99 |
| CHEMBL291266 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL286563 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL43184 | AMINACRINE | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL169949 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL289042 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL35478 | — | IC50 | > | 2000.0 | nM | - |