Assay Detail
Functional
CHEMBL705344
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxic activity was evaluated using the KB-3-1 resistant to adriamycin (ADR) subline KB-A1
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and cytotoxic activity of a new potent daunomycinone derivative.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.63 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119012 | — | — | 1 | 6.05 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 5.68 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119012 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 7010.0 | nM | 5.15 |