Assay Detail
Functional
CHEMBL705364
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Inhibitory activity against thymidylate synthase in Lactobacillus casei was determined (glutamate residue 5)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Lacticaseibacillus casei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.71 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 9.55 |
| CHEMBL293263 | — | — | 1 | 8.46 |
| CHEMBL296373 | EDATREXATE | 2.0 | 1 | 8.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL293263 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL296373 | EDATREXATE | IC50 | = | 7.4 | nM | 8.13 |