Assay Detail
Functional
CHEMBL705375
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Inhibition constant (Ki) was determined in Lactobacillus casei
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Lacticaseibacillus casei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel fluorinated antifolates. Enzyme inhibition and cytotoxicity studies on 2'- and 3'-fluoroaminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 10.07 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18925 | — | — | 1 | 10.22 |
| CHEMBL19227 | — | — | 1 | 10.02 |
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 9.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18925 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL19227 | — | Ki | = | 0.095 | nM | 10.02 |
| CHEMBL376180 | AMINOPTERIN | Ki | = | 0.11 | nM | 9.96 |