Assay Detail
Functional
CHEMBL705480
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Inhibitory concentration that reduced the viability of KB cell population by 50%.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.93 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.10 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.82 |
| CHEMBL74459 | — | — | 1 | 7.31 |
| CHEMBL72353 | — | — | 1 | 7.03 |
| CHEMBL304814 | — | — | 1 | 6.76 |
| CHEMBL72627 | — | — | 1 | 6.60 |
| CHEMBL73002 | — | — | 1 | 6.24 |
| CHEMBL72927 | — | — | 1 | 6.18 |
| CHEMBL266468 | — | — | 1 | 6.00 |
| CHEMBL312306 | — | — | 1 | 6.00 |
| CHEMBL311855 | — | — | 1 | 5.51 |
| CHEMBL74406 | — | — | 1 | 5.49 |
| CHEMBL265320 | — | — | 1 | 5.29 |
| CHEMBL386919 | — | — | 1 | 5.26 |
| CHEMBL72828 | — | — | 1 | 5.25 |
| CHEMBL64874 | — | — | 1 | 5.20 |
| CHEMBL11252 | STALLIMYCIN | 2.0 | 1 | 5.08 |
| CHEMBL70433 | — | — | 1 | 4.82 |
| CHEMBL307767 | NETROPSIN | — | 1 | 4.33 |
| CHEMBL312690 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL74459 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL72353 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL304814 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL72627 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL73002 | — | IC50 | = | 571.0 | nM | 6.24 |
| CHEMBL72927 | — | IC50 | = | 663.0 | nM | 6.18 |
| CHEMBL266468 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL312306 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL311855 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL74406 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL265320 | — | IC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL386919 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL72828 | — | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL64874 | — | IC50 | = | 6290.0 | nM | 5.20 |
| CHEMBL11252 | STALLIMYCIN | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL70433 | — | IC50 | = | 15290.0 | nM | 4.82 |
| CHEMBL307767 | NETROPSIN | IC50 | = | 47100.0 | nM | 4.33 |
| CHEMBL312690 | — | IC50 | = | 48080.0 | nM | 4.32 |