Assay Detail
Functional
CHEMBL705548
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Inhibitory activity against growth of L1210 cell line
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of chimeric structures derived from the cytotoxic natural compounds dolastatin 10 and dolastatin 15.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.38 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39541 | DOLASTATIN-10 | 2.0 | 1 | 10.52 |
| CHEMBL35769 | DOLASTATIN 15 | — | 1 | 9.89 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 9.14 |
| CHEMBL608244 | — | — | 1 | 8.80 |
| CHEMBL37030 | — | — | 1 | 8.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39541 | DOLASTATIN-10 | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL35769 | DOLASTATIN 15 | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL608244 | — | IC50 | = | 1.58 | nM | 8.80 |
| CHEMBL37030 | — | IC50 | = | 2.72 | nM | 8.56 |