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Assay Detail

CHEMBL705628

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Activity against lymphocytic murine leukemia cell line L1210 using MTS/PES microculture tetrazolium assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis, biological evaluation, and quantitative structure-activity relationship analysis of new Schiff bases of hydroxysemicarbazide as potential antitumor agents.
Ren S, Wang R, Komatsu K, Bonaz-Krause P, Zyrianov Y, McKenna CE, Csipke C, Tokes ZA, Lien EJ.
J Med Chem (2002) 45 : 410 -419
PubMed 11784145 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 4.70 5.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL131970 1 5.57
CHEMBL132252 1 5.36
CHEMBL423347 1 5.33
CHEMBL132081 1 5.27
CHEMBL440343 1 5.19
CHEMBL135007 1 5.14
CHEMBL133540 1 5.00
CHEMBL133345 1 4.97
CHEMBL341413 1 4.55
CHEMBL133879 1 4.52
CHEMBL134165 1 4.49
CHEMBL335639 1 4.42
CHEMBL134672 1 4.40
CHEMBL134014 1 4.37
CHEMBL133160 1 4.32
CHEMBL134041 1 4.22
CHEMBL467 HYDROXYUREA 4.0 1 4.09
CHEMBL340051 1 4.09
CHEMBL446163 1 4.04
CHEMBL903 HYDRAZINECARBOXAMIDE 1 -
CHEMBL131954 1 -
CHEMBL132189 1 -
CHEMBL135362 1 -
CHEMBL335959 1 -
CHEMBL134941 HYDROXYSEMICARBAZIDE 1 -
CHEMBL264637 1 -
CHEMBL134824 1 -
CHEMBL132717 1 -
CHEMBL131752 1 -
CHEMBL337647 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL131970 IC50 = 2700.0 nM 5.57
CHEMBL132252 IC50 = 4400.0 nM 5.36
CHEMBL423347 IC50 = 4700.0 nM 5.33
CHEMBL132081 IC50 = 5400.0 nM 5.27
CHEMBL440343 IC50 = 6500.0 nM 5.19
CHEMBL135007 IC50 = 7200.0 nM 5.14
CHEMBL133540 IC50 = 10100.0 nM 5.00
CHEMBL133345 IC50 = 10600.0 nM 4.97
CHEMBL341413 IC50 = 28200.0 nM 4.55
CHEMBL133879 IC50 = 30100.0 nM 4.52
CHEMBL134165 IC50 = 32200.0 nM 4.49
CHEMBL335639 IC50 = 37700.0 nM 4.42
CHEMBL134672 IC50 = 39500.0 nM 4.40
CHEMBL134014 IC50 = 42700.0 nM 4.37
CHEMBL133160 IC50 = 48100.0 nM 4.32
CHEMBL134041 IC50 = 60200.0 nM 4.22
CHEMBL467 HYDROXYUREA IC50 = 82000.0 nM 4.09
CHEMBL340051 IC50 = 80400.0 nM 4.09
CHEMBL446163 IC50 = 91400.0 nM 4.04
CHEMBL903 HYDRAZINECARBOXAMIDE IC50 = 2192000.0 nM -
CHEMBL131954 IC50 = 944100.0 nM -
CHEMBL132189 IC50 = 178300.0 nM -
CHEMBL135362 IC50 = 130800.0 nM -
CHEMBL335959 IC50 = 446300.0 nM -
CHEMBL134941 HYDROXYSEMICARBAZIDE IC50 = 281600.0 nM -
CHEMBL264637 IC50 = 820600.0 nM -
CHEMBL134824 IC50 = 891000.0 nM -
CHEMBL132717 IC50 = 476600.0 nM -
CHEMBL131752 IC50 = 399300.0 nM -
CHEMBL337647 IC50 = 607000.0 nM -
CHEMBL133649 IC50 = 368800.0 nM -
CHEMBL131959 IC50 = 316700.0 nM -
CHEMBL133594 IC50 = 208500.0 nM -