Assay Detail
Functional
CHEMBL705713
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Inhibition of L1210 cell growth
19
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.20 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349432 | — | — | 1 | 6.89 |
| CHEMBL355543 | — | — | 1 | 6.80 |
| CHEMBL170933 | — | — | 1 | 6.70 |
| CHEMBL354785 | — | — | 1 | 6.68 |
| CHEMBL353066 | — | — | 1 | 6.68 |
| CHEMBL168952 | — | — | 1 | 6.58 |
| CHEMBL170494 | — | — | 1 | 6.52 |
| CHEMBL170789 | — | — | 1 | 6.48 |
| CHEMBL170975 | — | — | 1 | 6.37 |
| CHEMBL367732 | — | — | 1 | 6.24 |
| CHEMBL168450 | — | — | 2 | 6.21 |
| CHEMBL263325 | — | — | 1 | 6.19 |
| CHEMBL168553 | — | — | 1 | 5.89 |
| CHEMBL352357 | — | — | 1 | 5.68 |
| CHEMBL349488 | — | — | 1 | 5.50 |
| CHEMBL169540 | — | — | 1 | 5.47 |
| CHEMBL424541 | — | — | 1 | 5.44 |
| CHEMBL352327 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349432 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL355543 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL170933 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL354785 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL353066 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL168952 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL170494 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL170789 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL170975 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL367732 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL168450 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL263325 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL168450 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL168553 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL352357 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL349488 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL169540 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL424541 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL352327 | — | IC50 | = | 4400.0 | nM | 5.36 |