Assay Detail
Functional
CHEMBL705717
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against resistant murine leukemia L1210 cell lines.
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.35 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44207 | — | — | 1 | 10.40 |
| CHEMBL43809 | — | — | 1 | 9.28 |
| CHEMBL40515 | — | — | 1 | 8.89 |
| CHEMBL42100 | — | — | 1 | 8.41 |
| CHEMBL42201 | — | — | 1 | 8.32 |
| CHEMBL40586 | — | — | 1 | 8.17 |
| CHEMBL40865 | — | — | 1 | 8.17 |
| CHEMBL40716 | — | — | 1 | 8.17 |
| CHEMBL40359 | — | — | 1 | 7.57 |
| CHEMBL40314 | — | — | 1 | 7.57 |
| CHEMBL41290 | — | — | 1 | 7.57 |
| CHEMBL41450 | — | — | 1 | 7.46 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.46 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 7.41 |
| CHEMBL42571 | — | — | 1 | 7.32 |
| CHEMBL289120 | — | — | 1 | 7.31 |
| CHEMBL40924 | — | — | 1 | 7.30 |
| CHEMBL40568 | — | — | 1 | 7.28 |
| CHEMBL42490 | — | — | 1 | 7.19 |
| CHEMBL40776 | — | — | 1 | 7.16 |
| CHEMBL288699 | — | — | 1 | 7.02 |
| CHEMBL288217 | — | — | 1 | 6.96 |
| CHEMBL40313 | — | — | 1 | 6.84 |
| CHEMBL416242 | — | — | 1 | 6.69 |
| CHEMBL41561 | — | — | 1 | 6.67 |
| CHEMBL43763 | — | — | 1 | 6.63 |
| CHEMBL43931 | — | — | 1 | 6.38 |
| CHEMBL290060 | — | — | 1 | 6.31 |
| CHEMBL43920 | — | — | 1 | 6.28 |
| CHEMBL287719 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44207 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL43809 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL40515 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL42100 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL42201 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL40586 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL40865 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL40716 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL40359 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL40314 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL41290 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL41450 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL42571 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL289120 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL40924 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL40568 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL42490 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL40776 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL288699 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL288217 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL40313 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL416242 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL41561 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL43763 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL43931 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL290060 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL43920 | — | IC50 | = | 524.0 | nM | 6.28 |
| CHEMBL287719 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL289729 | — | IC50 | = | 729.0 | nM | 6.14 |
| CHEMBL296224 | — | IC50 | = | 1225.0 | nM | 5.91 |