Assay Detail
Functional
CHEMBL705867
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cyclin-dependent kinase phosphorylation of S249-T252 of Rb protein in MCF-7 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Imidazo[1,2-a]pyridines. Part 2: SAR and optimisation of a potent and selective class of cyclin-dependent kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.85 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72548 | — | — | 1 | 7.30 |
| CHEMBL73243 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72548 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL73243 | — | IC50 | = | 400.0 | nM | 6.40 |