Assay Detail
Functional
CHEMBL705878
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Inhibition of MCF-7 cancer cell proliferation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Estrogen receptor ligands. Part 5: The SAR of dihydrobenzoxathiins containing modified basic side chains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.37 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334096 | — | — | 1 | 9.05 |
| CHEMBL122208 | — | — | 1 | 8.92 |
| CHEMBL121720 | — | — | 1 | 8.85 |
| CHEMBL125119 | — | — | 1 | 8.72 |
| CHEMBL332625 | — | — | 1 | 8.55 |
| CHEMBL121978 | — | — | 1 | 8.47 |
| CHEMBL124474 | — | — | 1 | 8.17 |
| CHEMBL122237 | — | — | 1 | 7.84 |
| CHEMBL340606 | — | — | 1 | 7.55 |
| CHEMBL121879 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334096 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL122208 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL121720 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL125119 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL332625 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL121978 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL124474 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL122237 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL340606 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL121879 | — | IC50 | = | 29.0 | nM | 7.54 |