Assay Detail
Functional
CHEMBL706061
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Compound concentration that reduces cell growth of L1210 leukemia cultures to 50% of controls after 70h.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potential antitumor agents. 56. "Minimal" DNA-intercalating ligands as antitumor drugs: phenylquinoline-8-carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.70 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9940 | — | — | 1 | 6.98 |
| CHEMBL9872 | — | — | 1 | 6.04 |
| CHEMBL9543 | — | — | 1 | 5.89 |
| CHEMBL9686 | — | — | 1 | 5.58 |
| CHEMBL267236 | — | — | 1 | 4.86 |
| CHEMBL276596 | — | — | 1 | 4.83 |
| CHEMBL9575 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9940 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL9872 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL9543 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL9686 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL267236 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL276596 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL9575 | — | IC50 | > | 25000.0 | nM | - |