Assay Detail
Functional
CHEMBL706062
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of L1210 cells in culture.
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.61 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307914 | — | — | 1 | 7.72 |
| CHEMBL169981 | — | — | 1 | 7.57 |
| CHEMBL104851 | — | — | 1 | 7.52 |
| CHEMBL321527 | — | — | 1 | 7.47 |
| CHEMBL307399 | — | — | 1 | 7.28 |
| CHEMBL104533 | — | — | 1 | 7.19 |
| CHEMBL104856 | — | — | 1 | 7.19 |
| CHEMBL70515 | — | — | 1 | 7.16 |
| CHEMBL105425 | — | — | 1 | 7.16 |
| CHEMBL105150 | — | — | 1 | 7.16 |
| CHEMBL104624 | — | — | 1 | 7.07 |
| CHEMBL105384 | — | — | 1 | 7.07 |
| CHEMBL434209 | — | — | 1 | 7.05 |
| CHEMBL320108 | — | — | 1 | 7.00 |
| CHEMBL40321 | — | — | 1 | 6.96 |
| CHEMBL104267 | — | — | 1 | 6.92 |
| CHEMBL104358 | — | — | 1 | 6.89 |
| CHEMBL73971 | — | — | 1 | 6.85 |
| CHEMBL105208 | — | — | 1 | 6.85 |
| CHEMBL323539 | — | — | 1 | 6.77 |
| CHEMBL104670 | — | — | 1 | 6.77 |
| CHEMBL104025 | — | — | 1 | 6.62 |
| CHEMBL323375 | — | — | 1 | 6.60 |
| CHEMBL323294 | — | — | 1 | 6.44 |
| CHEMBL44037 | — | — | 1 | 6.44 |
| CHEMBL104096 | — | — | 1 | 6.44 |
| CHEMBL320464 | — | — | 1 | 6.40 |
| CHEMBL104759 | — | — | 1 | 6.40 |
| CHEMBL320621 | — | — | 1 | 6.30 |
| CHEMBL105597 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307914 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL169981 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL104851 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL321527 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL307399 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL104533 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL104856 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL70515 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL105425 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL105150 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL105384 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL104624 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL434209 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL320108 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL40321 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL104267 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL104358 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL73971 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL105208 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL104670 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL323539 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL104025 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL323375 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL323294 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL44037 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL104096 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL320464 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL104759 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL320621 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL105597 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL319629 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL320470 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL105899 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL104871 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL102938 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL104748 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL102275 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL101425 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL104110 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL323363 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL105435 | — | IC50 | = | 18000.0 | nM | 4.75 |