Assay Detail
Functional
CHEMBL706065
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Compound was evaluated for inhibitory effect on growth of L1210 cells at IC50 (n=4)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.22 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428862 | — | — | 1 | 9.89 |
| CHEMBL12094 | — | — | 1 | 9.62 |
| CHEMBL11610 | — | — | 1 | 9.59 |
| CHEMBL275309 | — | — | 1 | 9.20 |
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 9.14 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.59 |
| CHEMBL262953 | — | — | 1 | 8.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428862 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL12094 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL11610 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL275309 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 2.55 | nM | 8.59 |
| CHEMBL262953 | — | IC50 | = | 2.85 | nM | 8.54 |