Assay Detail
Functional
CHEMBL706079
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Compound was tested for its ability to inhibit growth of L1210 mouse leukemia cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.79 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 8.70 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.70 |
| CHEMBL418165 | — | — | 1 | 6.40 |
| CHEMBL158478 | — | — | 1 | 6.36 |
| CHEMBL36083 | — | — | 1 | 5.89 |
| CHEMBL280864 | — | — | 1 | 5.89 |
| CHEMBL158970 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL418165 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL158478 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL36083 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL280864 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL158970 | — | IC50 | = | 2420.0 | nM | 5.62 |