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Assay Detail

CHEMBL706177

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Leukotriene A-4 hydrolase (CHEMBL4618)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of selective tight-binding inhibitors of leukotriene A4 hydrolase.
Yuan W, Munoz B, Wong CH, Haeggström JZ, Wetterholm A, Samuelsson B.
J Med Chem (1993) 36 : 211 -220
PubMed 8423594 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 5.01 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL71853 1 6.30
CHEMBL68679 1 6.22
CHEMBL68478 1 6.10
CHEMBL68958 1 5.52
CHEMBL302371 1 5.00
CHEMBL67989 1 4.70
CHEMBL70878 1 4.70
CHEMBL307799 1 4.70
CHEMBL67657 1 4.70
CHEMBL68518 1 4.10
CHEMBL71105 1 4.10
CHEMBL70599 1 4.00
CHEMBL68025 1 -
CHEMBL68818 1 -
CHEMBL414873 1 -
CHEMBL67917 1 -
CHEMBL71628 1 -
CHEMBL306190 1 -
CHEMBL69297 1 -
CHEMBL304393 1 -
CHEMBL69029 1 -
CHEMBL302932 1 -
CHEMBL304141 1 -
CHEMBL70920 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL71853 IC50 = 500.0 nM 6.30
CHEMBL68679 IC50 = 600.0 nM 6.22
CHEMBL68478 IC50 = 800.0 nM 6.10
CHEMBL68958 IC50 = 3000.0 nM 5.52
CHEMBL302371 IC50 = 10000.0 nM 5.00
CHEMBL67989 IC50 = 20000.0 nM 4.70
CHEMBL70878 IC50 = 20000.0 nM 4.70
CHEMBL307799 IC50 = 20000.0 nM 4.70
CHEMBL67657 IC50 = 20000.0 nM 4.70
CHEMBL68518 IC50 = 80000.0 nM 4.10
CHEMBL71105 IC50 = 80000.0 nM 4.10
CHEMBL70599 IC50 = 100000.0 nM 4.00
CHEMBL68025 IC50 > 100000.0 nM -
CHEMBL68818 IC50 > 100000.0 nM -
CHEMBL414873 IC50 = 250000.0 nM -
CHEMBL67917 IC50 > 1000000.0 nM -
CHEMBL71628 IC50 > 5000000.0 nM -
CHEMBL306190 IC50 > 100000.0 nM -
CHEMBL69297 IC50 = 140000.0 nM -
CHEMBL304393 IC50 > 100000.0 nM -
CHEMBL69029 IC50 > 500000.0 nM -
CHEMBL302932 IC50 > 1000000.0 nM -
CHEMBL304141 IC50 > 100000.0 nM -
CHEMBL70920 IC50 > 250000.0 nM -