Assay Detail
Binding
CHEMBL706180
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Inhibition of human leukotriene A4 hydrolase (LTA-4).
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of potent leukotriene A(4) hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.11 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323686 | — | — | 1 | 9.00 |
| CHEMBL119683 | — | — | 1 | 8.89 |
| CHEMBL117549 | — | — | 1 | 8.89 |
| CHEMBL326601 | — | — | 1 | 8.70 |
| CHEMBL543405 | — | — | 1 | 8.60 |
| CHEMBL421048 | — | — | 1 | 8.40 |
| CHEMBL119545 | — | — | 1 | 8.33 |
| CHEMBL117654 | — | — | 1 | 8.15 |
| CHEMBL119814 | — | — | 1 | 8.15 |
| CHEMBL420502 | — | — | 1 | 7.85 |
| CHEMBL116571 | — | — | 1 | 7.80 |
| CHEMBL326507 | — | — | 1 | 7.75 |
| CHEMBL117148 | — | — | 1 | 7.72 |
| CHEMBL420866 | — | — | 1 | 7.57 |
| CHEMBL117833 | — | — | 1 | 7.51 |
| CHEMBL117132 | — | — | 1 | 7.37 |
| CHEMBL117256 | — | — | 1 | 7.08 |
| CHEMBL117455 | — | — | 1 | 6.96 |
| CHEMBL119179 | — | — | 1 | 6.85 |
| CHEMBL119529 | — | — | 1 | 6.80 |
| CHEMBL115857 | — | — | 1 | 6.72 |
| CHEMBL119054 | — | — | 1 | 6.70 |
| CHEMBL119240 | — | — | 1 | 6.66 |
| CHEMBL325224 | — | — | 1 | 6.66 |
| CHEMBL117314 | — | — | 1 | 6.60 |
| CHEMBL331917 | — | — | 1 | 6.35 |
| CHEMBL119124 | — | — | 1 | 6.09 |
| CHEMBL332556 | — | — | 1 | 6.06 |
| CHEMBL419220 | — | — | 1 | 6.02 |
| CHEMBL118014 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323686 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL119683 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL117549 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL326601 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL543405 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL421048 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL119545 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL117654 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL119814 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL420502 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL116571 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL326507 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL117148 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL420866 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL117833 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL117132 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL117256 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL117455 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL119179 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL119529 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL115857 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL119054 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL119240 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL325224 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL117314 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL331917 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL119124 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL332556 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL419220 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL118014 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL116908 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL323873 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL119024 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL119422 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL117472 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL117231 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL119612 | — | IC50 | < | 0.5 | nM | - |