Assay Detail
Binding
CHEMBL706181
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Inhibitory activity against recombinant human Leukotriene A4 hydrolase
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Kelatorphan and related analogs: potent and selective inhibitors of leukotriene A4 hydrolase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.22 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86211 | — | — | 1 | 8.52 |
| CHEMBL315255 | — | — | 1 | 8.30 |
| CHEMBL85320 | KELATORPHAN | — | 1 | 8.30 |
| CHEMBL419305 | — | — | 1 | 8.10 |
| CHEMBL431019 | — | — | 1 | 8.00 |
| CHEMBL83291 | — | — | 1 | 8.00 |
| CHEMBL85430 | — | — | 1 | 7.92 |
| CHEMBL85512 | — | — | 1 | 7.52 |
| CHEMBL82898 | — | — | 1 | 6.52 |
| CHEMBL85542 | — | — | 1 | 5.75 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 5.00 |
| CHEMBL311933 | — | — | 1 | 4.70 |
| CHEMBL82343 | — | — | 1 | - |
| CHEMBL313284 | — | — | 1 | - |
| CHEMBL86201 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86211 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL315255 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL85320 | KELATORPHAN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL419305 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL431019 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL83291 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL85430 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL85512 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL82898 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL85542 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL311933 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL82343 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL313284 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL86201 | — | IC50 | > | 3000.0 | nM | - |