Assay Detail
Binding
CHEMBL706182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of recombinant human leukotriene A4 hydrolase.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.14 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273570 | — | — | 1 | 9.10 |
| CHEMBL279577 | — | — | 1 | 8.10 |
| CHEMBL14814 | — | — | 1 | 7.96 |
| CHEMBL14608 | — | — | 1 | 7.58 |
| CHEMBL14387 | — | — | 1 | 7.51 |
| CHEMBL14857 | — | — | 1 | 7.44 |
| CHEMBL14547 | — | — | 1 | 7.40 |
| CHEMBL14789 | — | — | 1 | 7.33 |
| CHEMBL276096 | — | — | 1 | 7.09 |
| CHEMBL441950 | — | — | 1 | 6.92 |
| CHEMBL279643 | — | — | 1 | 6.92 |
| CHEMBL14739 | — | — | 1 | 6.85 |
| CHEMBL14549 | — | — | 1 | 6.75 |
| CHEMBL416349 | — | — | 1 | 6.30 |
| CHEMBL14760 | — | — | 1 | 6.25 |
| CHEMBL14502 | — | — | 1 | 6.14 |
| CHEMBL15036 | — | — | 1 | 5.70 |
| CHEMBL14790 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273570 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL279577 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL14814 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL14608 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL14387 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL14857 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL14547 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL14789 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL276096 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL441950 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL279643 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL14739 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL14549 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL416349 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL14760 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL14502 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL15036 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL14790 | — | IC50 | > | 3000.0 | nM | - |