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Assay Detail

CHEMBL706228

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Functional
Growth inhibitory activity against L1210 cells (96h)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

A comparison of structure-activity relationships between spermidine and spermine analogue antineoplastics.
Bergeron RJ, Feng Y, Weimar WR, McManis JS, Dimova H, Porter C, Raisler B, Phanstiel O.
J Med Chem (1997) 40 : 1475 -1494
PubMed 9154970 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 5.59 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL37790 1 6.92
CHEMBL34476 1 6.75
CHEMBL37864 1 6.70
CHEMBL35522 1 6.46
CHEMBL37728 1 6.40
CHEMBL35633 1 6.40
CHEMBL28743 NORSPERMIDINE 1 6.30
CHEMBL33920 1 6.22
CHEMBL18027 1 6.16
CHEMBL34420 1 6.16
CHEMBL37489 1 6.05
CHEMBL34855 1 5.92
CHEMBL37490 1 5.77
CHEMBL36119 1 5.52
CHEMBL36610 1 5.40
CHEMBL29194 1 5.32
CHEMBL33916 1 5.22
CHEMBL38200 1 5.22
CHEMBL38250 1 5.00
CHEMBL33912 1 4.55
CHEMBL441413 1 4.48
CHEMBL36145 1 4.40
CHEMBL284260 1 4.26
CHEMBL30952 1 4.22
CHEMBL37716 1 4.00
CHEMBL37901 1 -
CHEMBL19612 SPERMIDINE 3.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL37790 IC50 = 120.0 nM 6.92
CHEMBL34476 IC50 = 180.0 nM 6.75
CHEMBL37864 IC50 = 200.0 nM 6.70
CHEMBL35522 IC50 = 350.0 nM 6.46
CHEMBL37728 IC50 = 400.0 nM 6.40
CHEMBL35633 IC50 = 400.0 nM 6.40
CHEMBL28743 NORSPERMIDINE IC50 = 500.0 nM 6.30
CHEMBL33920 IC50 = 600.0 nM 6.22
CHEMBL18027 IC50 = 700.0 nM 6.16
CHEMBL34420 IC50 = 700.0 nM 6.16
CHEMBL37489 IC50 = 900.0 nM 6.05
CHEMBL34855 IC50 = 1200.0 nM 5.92
CHEMBL37490 IC50 = 1700.0 nM 5.77
CHEMBL36119 IC50 = 3000.0 nM 5.52
CHEMBL36610 IC50 = 4000.0 nM 5.40
CHEMBL29194 IC50 = 4800.0 nM 5.32
CHEMBL33916 IC50 = 6000.0 nM 5.22
CHEMBL38200 IC50 = 6000.0 nM 5.22
CHEMBL38250 IC50 = 10000.0 nM 5.00
CHEMBL33912 IC50 = 28000.0 nM 4.55
CHEMBL441413 IC50 = 33000.0 nM 4.48
CHEMBL36145 IC50 = 40000.0 nM 4.40
CHEMBL284260 IC50 = 55000.0 nM 4.26
CHEMBL30952 IC50 = 60000.0 nM 4.22
CHEMBL37716 IC50 = 100000.0 nM 4.00
CHEMBL37901 IC50 > 100000.0 nM -
CHEMBL19612 SPERMIDINE IC50 > 100000.0 nM -