Assay Detail
Functional
CHEMBL706276
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Inhibition of LoVo human colon tumor cell proliferation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of 3-cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.51 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414139 | — | — | 1 | 6.72 |
| CHEMBL95002 | — | — | 1 | 6.60 |
| CHEMBL31733 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414139 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL95002 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL31733 | — | IC50 | = | 630.0 | nM | 6.20 |