Assay Detail
Functional
CHEMBL706328
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration required for antagonistic activity in MCF-7 cell lines derived from breast tumors that predominantly express ER-alpha
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.29 | 7.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330307 | — | — | 1 | 7.53 |
| CHEMBL93230 | — | — | 1 | 7.29 |
| CHEMBL89994 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330307 | — | IC50 | = | 29.8 | nM | 7.53 |
| CHEMBL93230 | — | IC50 | = | 51.3 | nM | 7.29 |
| CHEMBL89994 | — | IC50 | = | 86.6 | nM | 7.06 |