Assay Detail
Functional
CHEMBL706337
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Tested in vitro for inhibition after 48 hr exposure against murine leukemia cell line L1210 by experiment 2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and antitumor activity of a new class of pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone analogues of pyrrolo[1,4][2,1-c]benzodiazepines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.02 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137657 | — | — | 1 | 6.10 |
| CHEMBL436566 | — | — | 1 | 5.30 |
| CHEMBL335927 | — | — | 1 | 5.22 |
| CHEMBL137629 | — | — | 1 | 4.96 |
| CHEMBL300842 | — | — | 1 | 4.39 |
| CHEMBL137503 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137657 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL436566 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL335927 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL137629 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL300842 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL137503 | — | IC50 | = | 69000.0 | nM | 4.16 |