Assay Detail
Functional
CHEMBL706345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The IC50 was measured on L1210 cell lines incubated with compounds at concentration of 10 times the IC50 values and 10 uM thymidine 4)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.11 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6317 | — | — | 1 | 4.70 |
| CHEMBL6357 | — | — | 1 | 4.24 |
| CHEMBL6325 | — | — | 1 | 4.22 |
| CHEMBL268453 | — | — | 1 | 4.18 |
| CHEMBL6271 | — | — | 1 | 4.07 |
| CHEMBL266508 | — | — | 1 | 4.06 |
| CHEMBL268100 | — | — | 1 | 4.05 |
| CHEMBL6788 | — | — | 1 | 4.04 |
| CHEMBL6829 | — | — | 1 | 4.04 |
| CHEMBL266509 | — | — | 1 | 4.04 |
| CHEMBL6496 | — | — | 1 | 4.03 |
| CHEMBL266065 | — | — | 1 | 4.02 |
| CHEMBL6775 | — | — | 1 | 4.02 |
| CHEMBL6663 | — | — | 1 | 4.00 |
| CHEMBL267832 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6317 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL6357 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL6325 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL268453 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL6271 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL266508 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL268100 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL6788 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL6829 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL266509 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL6496 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL266065 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL6775 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL6663 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL267832 | — | IC50 | = | 100000.0 | nM | 4.00 |