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Assay Detail

CHEMBL706411

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration required to reduce incorporation of [3H]TdR in drug-treated cultures of intracellular Leishmania major to 50% of controls
ChEMBL ↗
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania major
Confidence 1 — Organism
Curated By Intermediate

Target

Leishmania major (CHEMBL612879) ↗
Type ORGANISM
Organism Leishmania major

Publication

Structure-activity relationships for the antileishmanial and antitrypanosomal activities of 1'-substituted 9-anilinoacridines.
Gamage SA, Figgitt DP, Wojcik SJ, Ralph RK, Ransijn A, Mauel J, Yardley V, Snowdon D, Croft SL, Denny WA.
J Med Chem (1997) 40 : 2634 -2642
PubMed 9258370 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 6.20 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL37644 — — 1 7.52
CHEMBL88461 — — 1 7.16
CHEMBL86823 — — 1 6.80
CHEMBL89031 — — 1 6.80
CHEMBL89458 — — 1 6.70
CHEMBL91079 — — 1 6.70
CHEMBL420434 — — 1 6.70
CHEMBL88980 — — 1 6.70
CHEMBL88123 — — 1 6.62
CHEMBL415472 — — 1 6.52
CHEMBL89519 — — 1 6.52
CHEMBL312941 — — 1 6.46
CHEMBL88507 — — 1 6.40
CHEMBL315530 — — 1 6.40
CHEMBL90679 — — 1 6.35
CHEMBL89400 — — 1 6.30
CHEMBL299581 — — 1 6.26
CHEMBL89171 — — 1 6.26
CHEMBL88682 — — 1 6.22
CHEMBL89150 — — 1 6.16
CHEMBL316058 — — 1 6.10
CHEMBL34941 — — 1 6.05
CHEMBL290441 — — 1 6.00
CHEMBL89758 — — 1 6.00
CHEMBL86724 — — 1 6.00
CHEMBL439951 — — 1 5.89
CHEMBL415467 — — 1 5.82
CHEMBL43 AMSACRINE 4.0 1 5.82
CHEMBL92012 — — 1 5.80
CHEMBL315133 — — 1 5.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL37644 — IC50 = 30.0 nM 7.52
CHEMBL88461 — IC50 = 70.0 nM 7.16
CHEMBL86823 — IC50 = 160.0 nM 6.80
CHEMBL89031 — IC50 = 160.0 nM 6.80
CHEMBL89458 — IC50 = 200.0 nM 6.70
CHEMBL91079 — IC50 = 200.0 nM 6.70
CHEMBL420434 — IC50 = 200.0 nM 6.70
CHEMBL88980 — IC50 = 200.0 nM 6.70
CHEMBL88123 — IC50 = 240.0 nM 6.62
CHEMBL415472 — IC50 = 300.0 nM 6.52
CHEMBL89519 — IC50 = 300.0 nM 6.52
CHEMBL312941 — IC50 = 350.0 nM 6.46
CHEMBL88507 — IC50 = 400.0 nM 6.40
CHEMBL315530 — IC50 = 400.0 nM 6.40
CHEMBL90679 — IC50 = 450.0 nM 6.35
CHEMBL89400 — IC50 = 500.0 nM 6.30
CHEMBL299581 — IC50 = 550.0 nM 6.26
CHEMBL89171 — IC50 = 550.0 nM 6.26
CHEMBL88682 — IC50 = 600.0 nM 6.22
CHEMBL89150 — IC50 = 700.0 nM 6.16
CHEMBL316058 — IC50 = 800.0 nM 6.10
CHEMBL34941 — IC50 = 900.0 nM 6.05
CHEMBL290441 — IC50 = 1000.0 nM 6.00
CHEMBL86724 — IC50 = 1000.0 nM 6.00
CHEMBL89758 — IC50 = 1000.0 nM 6.00
CHEMBL439951 — IC50 = 1300.0 nM 5.89
CHEMBL415467 — IC50 = 1500.0 nM 5.82
CHEMBL43 AMSACRINE IC50 = 1500.0 nM 5.82
CHEMBL92012 — IC50 = 1600.0 nM 5.80
CHEMBL315133 — IC50 = 1800.0 nM 5.75
CHEMBL36404 — IC50 = 2000.0 nM 5.70
CHEMBL89683 — IC50 = 2000.0 nM 5.70
CHEMBL289352 — IC50 = 2100.0 nM 5.68
CHEMBL49436 — IC50 = 2700.0 nM 5.57
CHEMBL92157 — IC50 = 3600.0 nM 5.44
CHEMBL84678 — IC50 = 3900.0 nM 5.41
CHEMBL34804 — IC50 = 5000.0 nM 5.30
CHEMBL37940 — IC50 > 3000.0 nM -
CHEMBL290443 — IC50 > 3000.0 nM -
CHEMBL421351 — IC50 > 3000.0 nM -
CHEMBL328232 — IC50 > 3000.0 nM -
CHEMBL295949 — IC50 > 3000.0 nM -
CHEMBL37615 — IC50 > 3000.0 nM -
CHEMBL89802 — IC50 > 3000.0 nM -