Assay Detail
Functional
CHEMBL706501
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Tested for the cytotoxicity in LS174T cells after activation by enzyme nitroreductase/NADH
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LS174T |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.12 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65162 | — | — | 1 | 5.30 |
| CHEMBL294279 | — | — | 1 | 5.19 |
| CHEMBL387060 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65162 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL294279 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL387060 | — | IC50 | = | 13700.0 | nM | 4.86 |