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Assay Detail

CHEMBL706601

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Leucine aminopeptidase isolated from porcine kidney.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cytosol aminopeptidase (CHEMBL3965)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Phosphorus amino acid analogues as inhibitors of leucine aminopeptidase.
Giannousis PP, Bartlett PA.
J Med Chem (1987) 30 : 1603 -1609
PubMed 3625708 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 4.94 6.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL40422 LEUCINE PHOSPHONIC ACID 1 6.64
CHEMBL40813 1 6.38
CHEMBL40508 1 6.00
CHEMBL289264 1 4.81
CHEMBL40965 1 4.40
CHEMBL296889 1 4.37
CHEMBL42982 1 4.25
CHEMBL1160058 1 4.24
CHEMBL37846 1 4.23
CHEMBL39768 1 4.06
CHEMBL1160057 1 -
CHEMBL288165 1 -
CHEMBL296494 1 -
CHEMBL43630 1 -
CHEMBL41873 1 -
CHEMBL41600 1 -
CHEMBL42003 ISOAMYLAMINE 1 -
CHEMBL40534 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL40422 LEUCINE PHOSPHONIC ACID Ki = 230.0 nM 6.64
CHEMBL40813 Ki = 420.0 nM 6.38
CHEMBL40508 Ki = 1000.0 nM 6.00
CHEMBL289264 Ki = 15400.0 nM 4.81
CHEMBL40965 Ki = 40000.0 nM 4.40
CHEMBL296889 Ki = 43000.0 nM 4.37
CHEMBL42982 Ki = 56000.0 nM 4.25
CHEMBL1160058 Ki = 58000.0 nM 4.24
CHEMBL37846 Ki = 59000.0 nM 4.23
CHEMBL39768 Ki = 87000.0 nM 4.06
CHEMBL1160057 Ki = 340000.0 nM -
CHEMBL288165 Ki = 220000.0 nM -
CHEMBL296494 Ki = 240000.0 nM -
CHEMBL43630 Ki = 1650000.0 nM -
CHEMBL41873 Ki = 1040000.0 nM -
CHEMBL41600 Ki = 775000.0 nM -
CHEMBL42003 ISOAMYLAMINE Ki > 50000000.0 nM -
CHEMBL40534 Ki = 320000.0 nM -