Assay Detail
Functional
CHEMBL706623
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Compound was tested for its inhibitory concentration to inhibit the growth of wild type L1210 cells.
11
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.28 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.70 |
| CHEMBL376180 | AMINOPTERIN | 2.0 | 2 | 8.70 |
| CHEMBL44693 | — | — | 1 | 8.54 |
| CHEMBL47316 | — | — | 1 | 8.49 |
| CHEMBL45735 | — | — | 2 | 8.46 |
| CHEMBL45679 | — | — | 2 | 8.22 |
| CHEMBL46656 | — | — | 2 | 8.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL44693 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL47316 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL45735 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL45735 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL45679 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL46656 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL46656 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL45679 | — | IC50 | = | 37.0 | nM | 7.43 |