Assay Detail
Functional
CHEMBL706627
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Tested for the concentration to inhibit 50% of L1210 cell growth in culture.
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.60 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225071 | RALTITREXED | 4.0 | 1 | 8.15 |
| CHEMBL71952 | — | — | 1 | 7.58 |
| CHEMBL71035 | — | — | 1 | 7.44 |
| CHEMBL302821 | — | — | 1 | 7.40 |
| CHEMBL70995 | — | — | 1 | 7.28 |
| CHEMBL309008 | — | — | 1 | 7.22 |
| CHEMBL70427 | — | — | 1 | 7.16 |
| CHEMBL70515 | — | — | 1 | 7.16 |
| CHEMBL434209 | — | — | 1 | 7.05 |
| CHEMBL40321 | — | — | 1 | 6.96 |
| CHEMBL74059 | — | — | 1 | 6.77 |
| CHEMBL71366 | — | — | 1 | 6.52 |
| CHEMBL69232 | — | — | 1 | 6.46 |
| CHEMBL74229 | — | — | 1 | 6.42 |
| CHEMBL72608 | — | — | 1 | 6.38 |
| CHEMBL71177 | — | — | 1 | 6.27 |
| CHEMBL68806 | — | — | 1 | 6.18 |
| CHEMBL74064 | — | — | 1 | 6.16 |
| CHEMBL74180 | — | — | 1 | 6.10 |
| CHEMBL307949 | — | — | 1 | 5.89 |
| CHEMBL308586 | — | — | 1 | 5.62 |
| CHEMBL68969 | — | — | 1 | 5.52 |
| CHEMBL306305 | — | — | 1 | 5.52 |
| CHEMBL70289 | — | — | 1 | 5.21 |
| CHEMBL72049 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225071 | RALTITREXED | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL71952 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL71035 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL302821 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL70995 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL309008 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL70427 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL70515 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL434209 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL40321 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL74059 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL71366 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL69232 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL74229 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL72608 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL71177 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL68806 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL74064 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL74180 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL307949 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL308586 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL68969 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL306305 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL70289 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL72049 | — | IC50 | > | 20000.0 | nM | - |