Assay Detail
Functional
CHEMBL706643
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against human chronic myelogenous leukemia K562 cell growth
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.25 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | 4.0 | 1 | 9.00 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.00 |
| CHEMBL116173 | — | — | 1 | 7.70 |
| CHEMBL276625 | PHENSTATIN | — | 1 | 7.70 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.70 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.70 |
| CHEMBL112385 | — | — | 1 | 7.22 |
| CHEMBL115360 | — | — | 1 | 7.22 |
| CHEMBL113332 | — | — | 1 | 7.16 |
| CHEMBL115499 | — | — | 1 | 6.80 |
| CHEMBL321632 | — | — | 1 | 6.77 |
| CHEMBL112192 | — | — | 1 | 6.60 |
| CHEMBL326388 | — | — | 1 | 6.22 |
| CHEMBL420862 | — | — | 1 | 6.22 |
| CHEMBL325432 | — | — | 1 | 6.16 |
| CHEMBL115488 | — | — | 1 | 6.14 |
| CHEMBL419387 | — | — | 1 | 6.10 |
| CHEMBL114651 | — | — | 1 | 6.10 |
| CHEMBL115055 | — | — | 1 | 6.05 |
| CHEMBL115451 | — | — | 1 | 5.85 |
| CHEMBL324797 | — | — | 1 | 5.85 |
| CHEMBL267340 | — | — | 1 | 5.70 |
| CHEMBL114428 | — | — | 1 | 5.52 |
| CHEMBL422965 | — | — | 1 | 5.40 |
| CHEMBL115002 | — | — | 1 | 5.22 |
| CHEMBL114642 | — | — | 1 | 5.16 |
| CHEMBL114677 | — | — | 1 | 4.70 |
| CHEMBL114423 | — | — | 1 | 4.66 |
| CHEMBL326114 | — | — | 1 | 4.60 |
| CHEMBL113837 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL116173 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL276625 | PHENSTATIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL107 | COLCHICINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL112385 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL115360 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL113332 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL115499 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL321632 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL112192 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL326388 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL420862 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL325432 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL115488 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL419387 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL114651 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL115055 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL115451 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL324797 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL267340 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL114428 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL422965 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL115002 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL114642 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL114677 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL114423 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL326114 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL113837 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL326395 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL113770 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL115490 | — | IC50 | > | 80000.0 | nM | - |