Assay Detail
Functional
CHEMBL706770
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Effective concentration against HIV infected MT-2 cell line
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design, synthesis, and activity of conformationally-constrained macrocyclic peptide-based inhibitors of HIV protease
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.58 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68313 | — | — | 1 | 8.40 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 8.30 |
| CHEMBL72386 | — | — | 1 | 8.10 |
| CHEMBL433309 | — | — | 1 | 8.10 |
| CHEMBL70787 | — | — | 1 | 7.85 |
| CHEMBL305466 | — | — | 1 | 7.77 |
| CHEMBL431754 | — | — | 1 | 7.75 |
| CHEMBL306897 | — | — | 1 | 7.70 |
| CHEMBL431387 | — | — | 1 | 7.58 |
| CHEMBL72474 | — | — | 1 | 7.54 |
| CHEMBL431569 | — | — | 1 | 7.51 |
| CHEMBL306727 | — | — | 1 | 7.44 |
| CHEMBL305063 | — | — | 1 | 6.67 |
| CHEMBL430984 | — | — | 1 | 6.50 |
| CHEMBL305463 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68313 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL114 | SAQUINAVIR | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL72386 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL433309 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL70787 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL305466 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL431754 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL306897 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL431387 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL72474 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL431569 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL306727 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL305063 | — | EC50 | = | 216.0 | nM | 6.67 |
| CHEMBL430984 | — | EC50 | = | 315.0 | nM | 6.50 |
| CHEMBL305463 | — | EC50 | = | 378.0 | nM | 6.42 |