Assay Detail
Functional
CHEMBL706979
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Growth inhibition against Leishmania major promastigotes in culture
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania major |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 4.77 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.00 |
| CHEMBL21254 | — | — | 1 | 5.10 |
| CHEMBL20587 | — | — | 1 | 5.07 |
| CHEMBL20424 | — | — | 1 | 4.64 |
| CHEMBL282044 | — | — | 1 | 4.60 |
| CHEMBL20466 | — | — | 1 | 4.29 |
| CHEMBL20227 | — | — | 1 | 4.24 |
| CHEMBL21077 | — | — | 1 | 4.22 |
| CHEMBL20480 | — | — | 1 | - |
| CHEMBL20368 | — | — | 1 | - |
| CHEMBL418741 | — | — | 1 | - |
| CHEMBL20628 | — | — | 1 | - |
| CHEMBL20393 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL21254 | — | EC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL20587 | — | EC50 | = | 8511.38 | nM | 5.07 |
| CHEMBL20424 | — | EC50 | = | 22908.68 | nM | 4.64 |
| CHEMBL282044 | — | EC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL20466 | — | EC50 | = | 51286.14 | nM | 4.29 |
| CHEMBL20227 | — | EC50 | = | 57543.99 | nM | 4.24 |
| CHEMBL21077 | — | EC50 | = | 60255.96 | nM | 4.22 |
| CHEMBL20480 | — | EC50 | = | 218776.16 | nM | - |
| CHEMBL20368 | — | EC50 | = | 501187.23 | nM | - |
| CHEMBL418741 | — | EC50 | = | 309029.54 | nM | - |
| CHEMBL20628 | — | EC50 | = | 125892.54 | nM | - |
| CHEMBL20393 | — | EC50 | = | 263026.8 | nM | - |