Assay Detail
Functional
CHEMBL707102
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In vitro inhibition of L1210 cell growth in rodent neoplastic cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.33 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 8.92 |
| CHEMBL166915 | — | — | 1 | 8.85 |
| CHEMBL354055 | — | — | 1 | 8.66 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.57 |
| CHEMBL171757 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL166915 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL354055 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL171757 | — | IC50 | = | 217.0 | nM | 6.66 |