Assay Detail
Functional
CHEMBL707111
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In vitro inhibitory activity against L1210 cell growth
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Quinazoline antifolates thymidylate synthase inhibitors: lipophilic analogues with modification to the C2-methyl substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.65 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444797 | — | — | 1 | 7.12 |
| CHEMBL25889 | — | — | 1 | 6.82 |
| CHEMBL268453 | — | — | 1 | 6.58 |
| CHEMBL349448 | — | — | 1 | 6.47 |
| CHEMBL161033 | — | — | 1 | 6.24 |
| CHEMBL162349 | — | — | 1 | 6.24 |
| CHEMBL159591 | — | — | 1 | 6.19 |
| CHEMBL159642 | — | — | 1 | 6.17 |
| CHEMBL159803 | — | — | 1 | 6.16 |
| CHEMBL162891 | — | — | 1 | 6.16 |
| CHEMBL159655 | — | — | 1 | 6.02 |
| CHEMBL6325 | — | — | 1 | 5.85 |
| CHEMBL162297 | — | — | 1 | 5.72 |
| CHEMBL159633 | — | — | 1 | 5.70 |
| CHEMBL158807 | — | — | 1 | 5.66 |
| CHEMBL349196 | — | — | 1 | 5.62 |
| CHEMBL423243 | — | — | 1 | 5.57 |
| CHEMBL164315 | — | — | 1 | 5.32 |
| CHEMBL159501 | — | — | 1 | 5.30 |
| CHEMBL234704 | — | — | 1 | 5.30 |
| CHEMBL159593 | — | — | 1 | 5.30 |
| CHEMBL161081 | — | — | 1 | 5.28 |
| CHEMBL349365 | — | — | 1 | 5.17 |
| CHEMBL159584 | — | — | 1 | 5.11 |
| CHEMBL159227 | — | — | 1 | 5.11 |
| CHEMBL348765 | — | — | 1 | 5.05 |
| CHEMBL163990 | — | — | 1 | 5.05 |
| CHEMBL435856 | — | — | 1 | 4.96 |
| CHEMBL161349 | — | — | 1 | 4.92 |
| CHEMBL351599 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444797 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL25889 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL268453 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL349448 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL161033 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL162349 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL159591 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL159642 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL159803 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL162891 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL159655 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL6325 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL162297 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL159633 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL158807 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL349196 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL423243 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL164315 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL159501 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL234704 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL159593 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL161081 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL349365 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL159584 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL159227 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL348765 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL163990 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL435856 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL161349 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL351599 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL161642 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL161641 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL161049 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL351864 | — | IC50 | > | 20000.0 | nM | - |