Assay Detail
Functional
CHEMBL707142
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Compound was tested in vitro for cytotoxicity against L1210 murine cell line (48 hr exposure to compound)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
8,11-dihydroxy-6-[(aminoalkyl)amino]-7H-benzo[e]perimidin-7-ones with activity in multidrug-resistant cell lines: synthesis and antitumor evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.91 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418866 | — | — | 1 | 8.89 |
| CHEMBL116091 | — | — | 1 | 8.45 |
| CHEMBL119703 | — | — | 1 | 8.42 |
| CHEMBL116415 | — | — | 1 | 8.18 |
| CHEMBL119334 | — | — | 1 | 8.04 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 7.94 |
| CHEMBL118423 | — | — | 1 | 7.89 |
| CHEMBL116295 | — | — | 1 | 7.71 |
| CHEMBL49442 | AMETANTRONE | 2.0 | 1 | 6.84 |
| CHEMBL334256 | — | — | 1 | 6.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418866 | — | IC50 | = | 1.29 | nM | 8.89 |
| CHEMBL116091 | — | IC50 | = | 3.55 | nM | 8.45 |
| CHEMBL119703 | — | IC50 | = | 3.79 | nM | 8.42 |
| CHEMBL116415 | — | IC50 | = | 6.59 | nM | 8.18 |
| CHEMBL119334 | — | IC50 | = | 9.02 | nM | 8.04 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL118423 | — | IC50 | = | 12.97 | nM | 7.89 |
| CHEMBL116295 | — | IC50 | = | 19.52 | nM | 7.71 |
| CHEMBL49442 | AMETANTRONE | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL334256 | — | IC50 | = | 203.0 | nM | 6.69 |