Assay Detail
Functional
CHEMBL707143
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Compound was tested in vitro for cytotoxicity against L1210 murine leukemia cells.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antitumor activity of a new class of water soluble camptothecin derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.12 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274070 | 9-AMINOCAMPTOTHECIN | 2.0 | 1 | 7.90 |
| CHEMBL545578 | — | — | 1 | 7.55 |
| CHEMBL542775 | — | — | 1 | 7.28 |
| CHEMBL540086 | — | — | 1 | 7.28 |
| CHEMBL543000 | — | — | 1 | 7.03 |
| CHEMBL554038 | — | — | 1 | 7.03 |
| CHEMBL543237 | — | — | 1 | 6.97 |
| CHEMBL540090 | — | — | 1 | 6.90 |
| CHEMBL555409 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274070 | 9-AMINOCAMPTOTHECIN | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL545578 | — | IC50 | = | 28.1 | nM | 7.55 |
| CHEMBL542775 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL540086 | — | IC50 | = | 52.4 | nM | 7.28 |
| CHEMBL543000 | — | IC50 | = | 92.5 | nM | 7.03 |
| CHEMBL554038 | — | IC50 | = | 94.5 | nM | 7.03 |
| CHEMBL543237 | — | IC50 | = | 107.7 | nM | 6.97 |
| CHEMBL540090 | — | IC50 | = | 124.9 | nM | 6.90 |
| CHEMBL555409 | — | IC50 | = | 688.8 | nM | 6.16 |