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Assay Detail

CHEMBL707145

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro test for cytotoxicity against L1210 murine leukemia cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Cytotoxic alpha-halogenoacrylic derivatives of distamycin A and congeners.
Beria I, Baraldi PG, Cozzi P, Caldarelli M, Geroni C, Marchini S, Mongelli N, Romagnoli R.
J Med Chem (2004) 47 : 2611 -2623
PubMed 15115402 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 8.02 8.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL545016 1 8.90
CHEMBL544920 1 8.83
CHEMBL545616 1 8.73
CHEMBL537929 1 8.73
CHEMBL557138 1 8.61
CHEMBL554690 1 8.57
CHEMBL543135 1 8.42
CHEMBL556373 1 8.42
CHEMBL88481 1 8.38
CHEMBL556031 1 8.20
CHEMBL553818 1 8.14
CHEMBL265546 1 8.07
CHEMBL87988 1 8.05
CHEMBL87748 1 7.75
CHEMBL539788 1 7.68
CHEMBL544919 1 7.64
CHEMBL88482 1 7.31
CHEMBL543738 1 7.01
CHEMBL544442 1 7.00
CHEMBL542800 1 5.89
CHEMBL545614 1 -
CHEMBL564096 1 -
CHEMBL542318 1 -
CHEMBL554387 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL545016 IC50 = 1.26 nM 8.90
CHEMBL544920 IC50 = 1.48 nM 8.83
CHEMBL545616 IC50 = 1.86 nM 8.73
CHEMBL537929 IC50 = 1.85 nM 8.73
CHEMBL557138 IC50 = 2.46 nM 8.61
CHEMBL554690 IC50 = 2.67 nM 8.57
CHEMBL543135 IC50 = 3.81 nM 8.42
CHEMBL556373 IC50 = 3.8 nM 8.42
CHEMBL88481 IC50 = 4.13 nM 8.38
CHEMBL556031 IC50 = 6.3 nM 8.20
CHEMBL553818 IC50 = 7.2 nM 8.14
CHEMBL265546 IC50 = 8.58 nM 8.07
CHEMBL87988 IC50 = 9.0 nM 8.05
CHEMBL87748 IC50 = 18.0 nM 7.75
CHEMBL539788 IC50 = 20.7 nM 7.68
CHEMBL544919 IC50 = 23.0 nM 7.64
CHEMBL88482 IC50 = 48.9 nM 7.31
CHEMBL543738 IC50 = 96.8 nM 7.01
CHEMBL544442 IC50 = 98.8 nM 7.00
CHEMBL542800 IC50 = 1300.0 nM 5.89
CHEMBL545614 IC50 > 2500.0 nM -
CHEMBL564096 IC50 > 800.0 nM -
CHEMBL542318 IC50 > 700.0 nM -
CHEMBL554387 IC50 > 3000.0 nM -