Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL707148

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of L1210 cell growth by 50%
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Kinetic studies of the binding of acridinecarboxamide topoisomerase poisons to DNA: implications for mode of binding of ligands with uncharged chromophores.
Wakelin LP, Adams A, Denny WA.
J Med Chem (2002) 45 : 894 -901
PubMed 11831901 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.91 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL37656 1 7.82
CHEMBL9940 1 7.01
CHEMBL57685 1 6.82
CHEMBL158394 1 6.80
CHEMBL286237 1 6.37
CHEMBL434880 1 5.93
CHEMBL61030 1 5.86
CHEMBL164407 1 5.77
CHEMBL125475 1 5.77
CHEMBL171127 1 5.40
CHEMBL170970 1 5.39
CHEMBL162854 1 5.28
CHEMBL164209 1 5.20
CHEMBL354462 1 5.19
CHEMBL170957 1 5.18
CHEMBL161348 1 4.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL37656 IC50 = 15.0 nM 7.82
CHEMBL9940 IC50 = 98.0 nM 7.01
CHEMBL57685 IC50 = 150.0 nM 6.82
CHEMBL158394 IC50 = 160.0 nM 6.80
CHEMBL286237 IC50 = 430.0 nM 6.37
CHEMBL434880 IC50 = 1170.0 nM 5.93
CHEMBL61030 IC50 = 1370.0 nM 5.86
CHEMBL164407 IC50 = 1715.0 nM 5.77
CHEMBL125475 IC50 = 1700.0 nM 5.77
CHEMBL171127 IC50 = 4000.0 nM 5.40
CHEMBL170970 IC50 = 4100.0 nM 5.39
CHEMBL162854 IC50 = 5300.0 nM 5.28
CHEMBL164209 IC50 = 6300.0 nM 5.20
CHEMBL354462 IC50 = 6500.0 nM 5.19
CHEMBL170957 IC50 = 6600.0 nM 5.18
CHEMBL161348 IC50 = 17000.0 nM 4.77