Assay Detail
Functional
CHEMBL707173
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Compound was evaluated for the growth inhibition of mouse L1210 (impaired) cells.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Carboxylic acid bioisosteres of -linked dipeptide analogues of the folate-based thymidylate synthase (TS) inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.03 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157025 | — | — | 1 | 5.70 |
| CHEMBL160498 | — | — | 1 | 5.17 |
| CHEMBL157459 | — | — | 1 | 5.10 |
| CHEMBL156447 | — | — | 1 | 4.82 |
| CHEMBL160502 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157025 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL160498 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL157459 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL156447 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL160502 | — | IC50 | = | 44000.0 | nM | 4.36 |