Assay Detail
Functional
CHEMBL707201
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Inhibition of [3H]spermidine transport into MDA-MB-231 (human breast cancer) cells.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Amino acid/spermine conjugates: polyamine amides as potent spermidine uptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.63 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406117 | GUSPERIMUS | 3.0 | 1 | 7.09 |
| CHEMBL121187 | — | — | 1 | 7.07 |
| CHEMBL19612 | SPERMIDINE | 3.0 | 1 | 6.95 |
| CHEMBL25101 | — | — | 1 | 6.75 |
| CHEMBL313747 | JORO SPIDER TOXIN 3 | — | 1 | 6.72 |
| CHEMBL121124 | — | — | 1 | 6.59 |
| CHEMBL123001 | — | — | 1 | 6.58 |
| CHEMBL23194 | SPERMINE | 0.5 | 1 | 6.55 |
| CHEMBL121343 | — | — | 1 | 6.55 |
| CHEMBL120820 | — | — | 1 | 6.17 |
| CHEMBL46257 | PUTRESCINE | 3.0 | 1 | 5.89 |
| CHEMBL121239 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406117 | GUSPERIMUS | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL121187 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL19612 | SPERMIDINE | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL25101 | — | Ki | = | 178.0 | nM | 6.75 |
| CHEMBL313747 | JORO SPIDER TOXIN 3 | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL121124 | — | Ki | = | 256.0 | nM | 6.59 |
| CHEMBL123001 | — | Ki | = | 262.0 | nM | 6.58 |
| CHEMBL23194 | SPERMINE | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL121343 | — | Ki | = | 284.0 | nM | 6.55 |
| CHEMBL120820 | — | Ki | = | 672.0 | nM | 6.17 |
| CHEMBL46257 | PUTRESCINE | Ki | = | 1280.0 | nM | 5.89 |
| CHEMBL121239 | — | Ki | > | 1000.0 | nM | - |