Assay Detail
Functional
CHEMBL707229
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Inhibitory activity against Lactobacillus casei ATCC 7469
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Lacticaseibacillus casei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 9.34 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 10.52 |
| CHEMBL1160189 | — | — | 1 | 10.30 |
| CHEMBL1160188 | — | — | 1 | 10.10 |
| CHEMBL1160192 | — | — | 1 | 9.74 |
| CHEMBL1160181 | — | — | 1 | 9.46 |
| CHEMBL1160200 | — | — | 1 | 9.40 |
| CHEMBL49651 | — | — | 1 | 8.09 |
| CHEMBL48619 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL1160189 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL1160188 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL1160192 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL1160181 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL1160200 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL49651 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL48619 | — | IC50 | = | 86.0 | nM | 7.07 |