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Assay Detail

CHEMBL707236

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
LTB4 receptor binding from radioligand binding assay using human intact neutrophils PMN
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Leukotriene B4 receptor (CHEMBL2095160)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Structure-activity relationships study of two series of leukotriene B4 antagonists: novel indolyl and naphthyl compounds substituted with a 2-[methyl(2-phenethyl)amino]-2-oxoethyl side chain.
Chan WK, Huang FC, Morrissette MM, Warus JD, Moriarty KJ, Galemmo RA, Dankulich WD, Poli G, Sutherland CA.
J Med Chem (1996) 39 : 3756 -3768
PubMed 8809164 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 7.65 8.45

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL125646 1 8.45
CHEMBL328712 1 8.33
CHEMBL333079 1 8.30
CHEMBL122852 1 8.12
CHEMBL123486 1 8.11
CHEMBL333493 1 8.10
CHEMBL125723 1 8.08
CHEMBL340295 1 8.07
CHEMBL126200 1 8.05
CHEMBL122217 1 7.96
CHEMBL125117 1 7.95
CHEMBL341360 1 7.82
CHEMBL341116 1 7.78
CHEMBL122375 1 7.72
CHEMBL123201 1 7.72
CHEMBL126053 1 7.72
CHEMBL125476 1 7.70
CHEMBL3706723 1 7.69
CHEMBL127818 1 7.61
CHEMBL419419 1 7.60
CHEMBL332813 1 7.58
CHEMBL127340 1 7.46
CHEMBL122134 1 7.40
CHEMBL125559 1 7.30
CHEMBL125214 1 7.30
CHEMBL125013 1 7.28
CHEMBL121959 1 7.10
CHEMBL125131 1 7.05
CHEMBL125128 1 7.00
CHEMBL332348 1 6.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL125646 IC50 = 3.55 nM 8.45
CHEMBL328712 IC50 = 4.7 nM 8.33
CHEMBL333079 IC50 = 5.0 nM 8.30
CHEMBL122852 IC50 = 7.6 nM 8.12
CHEMBL123486 IC50 = 7.75 nM 8.11
CHEMBL333493 IC50 = 8.0 nM 8.10
CHEMBL125723 IC50 = 8.25 nM 8.08
CHEMBL340295 IC50 = 8.5 nM 8.07
CHEMBL126200 IC50 = 9.0 nM 8.05
CHEMBL122217 IC50 = 11.0 nM 7.96
CHEMBL125117 IC50 = 11.2 nM 7.95
CHEMBL341360 IC50 = 15.0 nM 7.82
CHEMBL341116 IC50 = 16.5 nM 7.78
CHEMBL122375 IC50 = 19.0 nM 7.72
CHEMBL126053 IC50 = 19.0 nM 7.72
CHEMBL123201 IC50 = 19.0 nM 7.72
CHEMBL125476 IC50 = 20.0 nM 7.70
CHEMBL3706723 IC50 = 20.3 nM 7.69
CHEMBL127818 IC50 = 24.5 nM 7.61
CHEMBL419419 IC50 = 25.0 nM 7.60
CHEMBL332813 IC50 = 26.3 nM 7.58
CHEMBL127340 IC50 = 35.0 nM 7.46
CHEMBL122134 IC50 = 40.0 nM 7.40
CHEMBL125559 IC50 = 50.0 nM 7.30
CHEMBL125214 IC50 = 50.0 nM 7.30
CHEMBL125013 IC50 = 53.0 nM 7.28
CHEMBL121959 IC50 = 80.0 nM 7.10
CHEMBL125131 IC50 = 90.0 nM 7.05
CHEMBL125128 IC50 = 100.0 nM 7.00
CHEMBL332348 IC50 = 250.0 nM 6.60
CHEMBL333273 IC50 = 700.0 nM 6.16